Research Labs

Al-Quds Cognitive Neuroscience Lab

Dr. Mohammad Hirzallah / Director

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  • Phone: +1 973 353 3669
  • Fax:     +1 973 353 1272
  • Website: http://neuroscience.med.alquds.edu
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Biodiversity Research Lab

Khaled Sawalha

  • Assistant Professor of Botany
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  • T: +972-02-2799753

Biophysics Research Lab

Contact persons

Saqer M Darwish

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  • Tel:0599112281

Musa Abuteir

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  • Tel:0597871044

Address: Biophysics Research Lab- College of science & technology, Al-Quds University, Jerusalem, Palestine.

About

  • The lab was established by funding from The German Research foundation DFG in 2006
  • The research lab provide services for students and faculty members in physics, biology, chemistry, Nanotechnology, and environmental science programs.
  • The experimental research at our lab can contribute to the understanding of the secondary structure of the proteins and its complications which possibly leads to amyloidosis and may contribute in preventing such diseases.

The research group

  • SaqerDarwish, Ph.D. physics,
  • Musa Abuteir, Ph.D Physics,
  • Sawsan Abu–Sharkh Ph.D. Biophysics.
  • HussainAlsamamrehPh.D physics
  • Imtiaz Khalid- Ph.D. Chemistry

Research activities

Our research activities focus on studying the interactions between proteins and a variety of drugs such as pentobarbital, propofol, arginine, cholesterols and vitamins. Also studies the effects of ELF magnetic fields on proteins.

The research techniques involve FTIR spectroscopy, UV-VIS spectroscopy, fluorescence spectroscopy and atomic force resonance (AFM).

Recent publications:

  • Spectroscopic Investigations of β-Amyloid Interactions with Propofol and L-Arginine, Saqer M. Darwish1*, Shurook Y. Aiaidah, Imtiaz M. Khalid, Musa M. Abuteir, Lena Qawasmi, ojbiphy, 2015, 5, 50-67.
  • Spectroscopic approach of the interaction study of ceftriaxone and human serum albumin Abu Teir M. M., Ghithan J, Abu-Taha M. I, Darwish S. M. and Abu-hadid M. M, Journal of Biophysics and Structural Biology,vol 6 (1) (2014)1-12
  • Spectroscopic investigations of pentobarbital interaction with transthyretin, Saqer M. Darwish,*, JafarGithan, Musa M. Abu Teir, Sami A. Mariam Faroun. Mahmoud Abu-hadid, Journal of spectroscopy.2013(2013)1-10.
  • Multi-Spectroscopic Investigation of the Interactions between Cholesterol and Human Serum Albumin, M. Abu Teir* J. Ghithan S. Darwish M. M. Abu-Hadid Al-Quds University, Journal of Applied Biological Sciences 6 (3): 45-55, 2012
  • Study of Progesterone interaction with Human Serum Albumin: Spectroscopic approach M. M. Abu Teir*, J. H. Ghithan, S. M. Darwish, M. M. Abu-Hadid, Journal of Applied Biological Sciences 6 (3): 45-55, 2012
  • Spectroscopic investigations of Pentobarbital Interaction with Human Serum Albumin. Saqer M. Darwish a,*, Sawsan E. Abu sharkh a, Musa M. Abu Teir a, Sami A. Makharza ,Mahmoud M. Abu-hadid, Journal of Molecular Structure 963 (2010) 122–129
  • SPECTROSCOPIC STUDY OF PROPOFOL BINDING TO HUMAN SERUM ALBUMIN, Saqer M. Darwish,*, Sawsan E. Abu sharkh a, Musa M. Abu Teir a, Mahmoud M. Abu-hadid, Biophysical Reviews and Letters (BRL), 5(2010) pp.209-226.

Computational Chemistry and Drug Design Lab

Dr. Omar Deeb / Director

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Mobile: 0522387450

Drug Design and Discovery Lab

Center Director / Prof. Dr. Rafik Karaman

Team Members

  • Maryam Bader. “Synthesis and Characterization of Fumarate Esters Prodrugs for the Treatment of Psoriasis and Multiple Sclerosis: Al-Quds University, Jerusalem.
  • Alaa Qtait. “Synthesis, characterization and in vitro kinetics of novel Dopamine and Atenolol prodrugs”. Al-Quds University, Jerusalem.
  • Alaa Abu-Jaish. “Synthesis, Characterization and Evaluation of Potentially Useful NSAIDs Prodrugs and Co-drugs. Al-Quds University, Jerusalem.
  • Donia Karaman. “Design of novel prodrugs for Masking the Bitter Taste of Amoxicillin, Cephalexin and Paracetamol- A Computational Approach”. Al-Quds University, Jerusalem.
  • Hothaifa Kitaneh. “Synthesis of Derivatives of Bitter Taste Molecules Agonist and Antagonist”. Al-Quds University, Jerusalem.
  • Ibraheem Ayyad. “Biodegradation and Removal of Pharmaceutical Compound: Case Study Degradation of paracetamol, Pharmaceutical contains Amide Group by Pseudomonas Fluorescents”.  Al-Quds University, Jerusalem.
  • Yahya Khawaja. “Synthesis and in vitro kinetic study of Dopamine Prodrugs based on novel chemical approach”. Al-Quds University, Jerusalem.
  • Waad Horani. “Synthesis, Characterization and In-vitro Kinetics
    of cephalexin- and amoxicillin-diclofenac prodrugs”. Al-Quds University, Jerusalem.
  • Alia Al-Qadoumi. “Detoxification from Paracetamol Using Charcoal-Micelles Complexes”. Al-Quds University, Jerusalem.
  • Beesan Fattash.  “Synthesis and Characterization of New Anti-malarial Atovaquone Prodrug”. Al-Quds University, Jerusalem.
  • Hanadi Sonokrot.  “DFT Calculations for proton transfers in important biological systems”. Al-Quds University, Jerusalem.
  • Fatom Haddad.  “Synthesis and Characterization of gabapenthin Prodrugs”. Al-Quds University, Jerusalem.
  • Samer Khalaf. “Photodegradation of pesticides and NSAIDs pharmaceuticals”. Basilica University, Potenza, Italy & Al-Quds University, Palestine.
  • Ameen Thawabteh. “Design, synthesis and in vitro kinetic study of bitterless prodrugs for masking the bitter taste of bitterness drugs administered to pediatrics and geriatrics”. Basilicata University, Potenza, Italy& Al-Quds University, Palestine .

Research Activity

  • Design and synthesis of anti-cancer prodrugs having targeting properties which are determined on the linker’s type and nature. The variability in the pHs of the cancer and normal cell’s media plays a dominant role in the selection of the linker (promoiety). The design of these prodrugs will be executed using DFT, Ab initio and molecular mechanics methods.
  • Design, synthesis, characterization and in vitro and in vivo kinetics of pro-prodrug systems to be used for the delivery for certain drugs that have poor water solubility or/and have low bioavailability using ab initio, DFT, semiempirical, molecular mechanics as well as molecular dynamics and conformational dynamics methods. The in-vitro studies will be conducted in media mimics that of stomach (pH 1.2), intestine (pH 6.8) and blood circulation (pH 7.4). The in-vivo studies will be conducted in certain animals and the pharmacokinetic parameters will be determined using advanced technology such as, HPLC and LC-MS.
  • Design and synthesis of linkers to be used for masking bitter taste of drugs that contain a hydroxyl or amine groups (antimalarial, anti-hypertension, anti-bleeding, antibacterial and anticancer drugs) using DFT calculation methods. The synthesis will be carried out using standard organic methods and the kinetic rates of the intramolecular processes will be determined by HPLC monitoring.
  • Design and synthesis of bitter taste antagonists for inactivation of the bitter taste receptor 14.The design will be accomplished using molecular orbital and molecular mechanics methods.
  • Pharmaceuticals removal from wastewater using clay micelle complex, hollow fiber, spiral wounds, charcoal and other adsorbents.
  • Pharmaceuticals removal from wastewater using photodegradation methods such as light/TiO2.
  • Stability of Pharmaceuticals in wastewater and isolation and characterization of degradation products (metabolites).

Instruments / Sonicator, Microwave, Analytical balance, Ovens, Fridge, Hood & UV lamp.

Contact us

  • Address: College of Pharmacy, Al-Quds University, Jerusalem.
  • Tel. and Fax +970-2-2790413.
  • Cell. phone (Viber) +970 595587052
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Rafik Karaman (Biography)

Born: November 1957, Um El-Fahim City
Work: College of Pharmacy, Al-Quds University, Jerusalem
Palestine. Tel. and Fax +972-2-2790413.
Home: Ramallah, Palestine.
Nationality    USA and Israel
Affiliation:    Al-Quds University, Abu-Dies, Jerusalem, P.O. Box 20002, Palestine.

Professor Rafik Karaman is currently a Distinguished professor of pharmaceutical sciences, College of Pharmacy, Al-Quds University, Jerusalem, Palestine. He received his Ph.D. degree in bioorganic chemistry from the Hebrew University in 1987, his MS degree in Pharmaceutical Sciences from the Hebrew University in 1983, and his bachelor’s degree in Pharmacy from the Hebrew University in 1981. He was an Assistant Professor at the University of Toledo and University of California at Santa Barbara for 5 years where he worked with Professor T.C.Bruice in the bioorganic chemistry field. Professor Karaman is broadly interested in the design and synthesis of prodrug systems to be used for the delivery of certain drugs that have poor water solubility or/and have low bioavailability as well as synthesis of prodrugs for masking the bitter taste of the corresponding parent drugs. The design will be executed using ab initio, DFT, semiempirical, molecular mechanics as well as molecular dynamics and conformational dynamics methods. The overarching goal of his research activities is to establish a method for obtaining prodrugs that their interconversion rates will be controlled or programmed by the linker nature attached to their parent drugs. Professor Karaman has more than 160 peer-reviewed manuscripts and book chapters; 120 of them were published in the recent 9 years. He is currently an editor and an editorial board member of 39 international journals in the areas of pharmaceutical sciences.

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Laser & IR Spectroscopy Lab

Dr. Mohammad Abu Taha / Director

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Mobile: 0597-892291

Medical Research Center Molecular Genetics Laboratory

Dr. Hisham Darwish / Director

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Mobile: 0599822963

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Microbiology Research Lab

Dr. Dina Al-Bitar / Director

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Mobile: 0599-909975

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Nanotechnology Research Laboratory (NRL)

Overview

Nanotechnology is a revolution of endless possibilities. It is science, engineering, and technology conducted at the nanoscale. The Nanotechnology Research Laboratory was established in the year 2006 by Prof. Mukhles Sowwan through generous support from Al-Quds University and the German Research Foundation (DFG).

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Research in Medical Laboratory Sciences

Dr. Sameer Barghouthi / Director 

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Mobile: 0599-379561

Research Laboratory of Water and Environment

Director: Dr. Amer Marei

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Mobile: 0599203442

 

Soil & Hydrology Laboratory

Dr. Jawad Hasan Shoqeir

  • Associate Professor of Hydrogeology.
  • Earth and Environmental sciences Dep.
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  • Mobil: +972508573 Water and Environment
  • 714 or 00970595260865
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