Location: Health Complex Building (Sc025)
Faculty of Pharmacy
Equipment:
- Sonicator
- Microwave
- Analytical balance
- Ovens
- Fridge
- Hood & UV lamp.
Procedures:
Design and synthesis of anti-cancer prodrugs having targeting properties which are determined on the linker’s type and nature. The variability in the pHs of the cancer and normal cell’s media plays a dominant role in the selection of the linker (promoiety). The design of these prodrugs will be executed using DFT, Ab initio and molecular mechanics methods.
Design, synthesis, characterization and in vitro and in vivo kinetics of pro-prodrug systems to be used for the delivery for certain drugs that have poor water solubility or/and have low bioavailability using ab initio, DFT, semiempirical, molecular mechanics as well as molecular dynamics and conformational dynamics methods. The in-vitro studies will be conducted in media mimics that of stomach (pH 1.2), intestine (pH 6.8) and blood circulation (pH 7.4). The in-vivo studies will be conducted in certain animals and the pharmacokinetic parameters will be determined using advanced technology such as, HPLC and LC-MS.
Design and synthesis of linkers to be used for masking bitter taste of drugs that contain a hydroxyl or amine groups (antimalarial, anti-hypertension, anti-bleeding, antibacterial and anticancer drugs) using DFT calculation methods. The synthesis will be carried out using standard organic methods and the kinetic rates of the intramolecular processes will be determined by HPLC monitoring.
Design and synthesis of bitter taste antagonists for inactivation of the bitter taste receptor 14.The design will be accomplished using molecular orbital and molecular mechanics methods.
Pharmaceuticals removal from wastewater using clay micelle complex, hollow fiber, spiral wounds, charcoal and other adsorbents.
Pharmaceuticals removal from wastewater using photo degradation methods such as light/TiO2.
Stability of Pharmaceuticals in wastewater and isolation and characterization of degradation products (metabolites).
Director: Prof. Dr. Rafik Karaman
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
