Research Labs

Drug Design and Discovery Lab

Center Director / Prof. Dr. Rafik Karaman

Location: Health Complex Building (Sc025)

Team Members

  • Maryam Bader. “Synthesis and Characterization of Fumarate Esters Prodrugs for the Treatment of Psoriasis and Multiple Sclerosis: Al-Quds University, Jerusalem.
  • Alaa Qtait. “Synthesis, characterization and in vitro kinetics of novel Dopamine and Atenolol prodrugs”. Al-Quds University, Jerusalem.
  • Alaa Abu-Jaish. “Synthesis, Characterization and Evaluation of Potentially Useful NSAIDs Prodrugs and Co-drugs. Al-Quds University, Jerusalem.
  • Donia Karaman. “Design of novel prodrugs for Masking the Bitter Taste of Amoxicillin, Cephalexin and Paracetamol- A Computational Approach”. Al-Quds University, Jerusalem.
  • Hothaifa Kitaneh. “Synthesis of Derivatives of Bitter Taste Molecules Agonist and Antagonist”. Al-Quds University, Jerusalem.
  • Ibraheem Ayyad. “Biodegradation and Removal of Pharmaceutical Compound: Case Study Degradation of paracetamol, Pharmaceutical contains Amide Group by Pseudomonas Fluorescents”.  Al-Quds University, Jerusalem.
  • Yahya Khawaja. “Synthesis and in vitro kinetic study of Dopamine Prodrugs based on novel chemical approach”. Al-Quds University, Jerusalem.
  • Waad Horani. “Synthesis, Characterization and In-vitro Kinetics
    of cephalexin- and amoxicillin-diclofenac prodrugs”. Al-Quds University, Jerusalem.
  • Alia Al-Qadoumi. “Detoxification from Paracetamol Using Charcoal-Micelles Complexes”. Al-Quds University, Jerusalem.
  • Beesan Fattash.  “Synthesis and Characterization of New Anti-malarial Atovaquone Prodrug”. Al-Quds University, Jerusalem.
  • Hanadi Sonokrot.  “DFT Calculations for proton transfers in important biological systems”. Al-Quds University, Jerusalem.
  • Fatom Haddad.  “Synthesis and Characterization of gabapenthin Prodrugs”. Al-Quds University, Jerusalem.
  • Samer Khalaf. “Photodegradation of pesticides and NSAIDs pharmaceuticals”. Basilica University, Potenza, Italy & Al-Quds University, Palestine.
  • Ameen Thawabteh. “Design, synthesis and in vitro kinetic study of bitterless prodrugs for masking the bitter taste of bitterness drugs administered to pediatrics and geriatrics”. Basilicata University, Potenza, Italy& Al-Quds University, Palestine .

Research Activity

  • Design and synthesis of anti-cancer prodrugs having targeting properties which are determined on the linker’s type and nature. The variability in the pHs of the cancer and normal cell’s media plays a dominant role in the selection of the linker (promoiety). The design of these prodrugs will be executed using DFT, Ab initio and molecular mechanics methods.
  • Design, synthesis, characterization and in vitro and in vivo kinetics of pro-prodrug systems to be used for the delivery for certain drugs that have poor water solubility or/and have low bioavailability using ab initio, DFT, semiempirical, molecular mechanics as well as molecular dynamics and conformational dynamics methods. The in-vitro studies will be conducted in media mimics that of stomach (pH 1.2), intestine (pH 6.8) and blood circulation (pH 7.4). The in-vivo studies will be conducted in certain animals and the pharmacokinetic parameters will be determined using advanced technology such as, HPLC and LC-MS.
  • Design and synthesis of linkers to be used for masking bitter taste of drugs that contain a hydroxyl or amine groups (antimalarial, anti-hypertension, anti-bleeding, antibacterial and anticancer drugs) using DFT calculation methods. The synthesis will be carried out using standard organic methods and the kinetic rates of the intramolecular processes will be determined by HPLC monitoring.
  • Design and synthesis of bitter taste antagonists for inactivation of the bitter taste receptor 14.The design will be accomplished using molecular orbital and molecular mechanics methods.
  • Pharmaceuticals removal from wastewater using clay micelle complex, hollow fiber, spiral wounds, charcoal and other adsorbents.
  • Pharmaceuticals removal from wastewater using photodegradation methods such as light/TiO2.
  • Stability of Pharmaceuticals in wastewater and isolation and characterization of degradation products (metabolites).

Instruments / Sonicator, Microwave, Analytical balance, Ovens, Fridge, Hood & UV lamp.

Contact us

  • Address: College of Pharmacy, Al-Quds University, Jerusalem.
  • Tel. and Fax +970-2-2790413.
  • Cell. phone (Viber) +970 595587052
  • E-mail address- This email address is being protected from spambots. You need JavaScript enabled to view it. 

Rafik Karaman (Biography)

Born: November 1957, Um El-Fahim City
Work: College of Pharmacy, Al-Quds University, Jerusalem
Palestine. Tel. and Fax +972-2-2790413.
Home: Ramallah, Palestine.
Nationality    USA and Israel
Affiliation:    Al-Quds University, Abu-Dies, Jerusalem, P.O. Box 20002, Palestine.

Professor Rafik Karaman is currently a Distinguished professor of pharmaceutical sciences, College of Pharmacy, Al-Quds University, Jerusalem, Palestine. He received his Ph.D. degree in bioorganic chemistry from the Hebrew University in 1987, his MS degree in Pharmaceutical Sciences from the Hebrew University in 1983, and his bachelor’s degree in Pharmacy from the Hebrew University in 1981. He was an Assistant Professor at the University of Toledo and University of California at Santa Barbara for 5 years where he worked with Professor T.C.Bruice in the bioorganic chemistry field. Professor Karaman is broadly interested in the design and synthesis of prodrug systems to be used for the delivery of certain drugs that have poor water solubility or/and have low bioavailability as well as synthesis of prodrugs for masking the bitter taste of the corresponding parent drugs. The design will be executed using ab initio, DFT, semiempirical, molecular mechanics as well as molecular dynamics and conformational dynamics methods. The overarching goal of his research activities is to establish a method for obtaining prodrugs that their interconversion rates will be controlled or programmed by the linker nature attached to their parent drugs. Professor Karaman has more than 160 peer-reviewed manuscripts and book chapters; 120 of them were published in the recent 9 years. He is currently an editor and an editorial board member of 39 international journals in the areas of pharmaceutical sciences.

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