On Sep 14th, 2021, Sundus Shalabi, at al. published a new study in the journal of Nature Aging entitled “Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations”. The article aimed to study whether aging phenotypes in mammary epithelia such as loss of lineage fidelity and differentiation defects are related to cancer susceptibility in general. The results of this study demonstrated that genetic high-risk mammary epithelial cells exhibit features of accelerated aging, such as the loss of cell-lineage markers, differentiation defects, and transcriptome-wide enrichment for genes related to aging and inflammation.
Here is a link to the article: https://www.nature.com/articles/s43587-021-00104-9, and here is a link to a news and views article that discusses the importance of its results: https://www.nature.com/articles/s43587-021-00113-8.
The story made it to the cover of the journal: https://www.nature.com/nataging.
For more information about the study, please contact Dr. Sundus Shalabi at: Sundus.f.shalabi@gmail or This email address is being protected from spambots. You need JavaScript enabled to view it.
