On November 3, 2017 , Omar Hamarsheh and others published a new study in Fitoterapia. 2018, volume 125, PP:191-198 titled "Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima" The study investigated the activity of three groups of natural products having an anti-trypanosomal activity in A. fragrantissima including sesquiterpene lactones, flavonoids, and alkamides, and a series of systematically varied alkamides were synthesized. Within this series, the compounds having heptyl or hexyloxy, respectively, in region R2 and a
basic amine moiety in region R1 were found to be highly active with high selectivity indices. The study showed that no toxicity was observed in an in vivo model utilizing Galleria mellonella in concentrations up to 20 mM. These compounds can be regarded as new leads. However, further work has to be performed to elucidate the mode of action of these compounds. Since the anti-trypanosomal activity.
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