Field of Research: Medical Chemistry
Name of author) (s): Abu Ali, H.,Fares,H., Darawsheh, M., Rappocciolo, E.,Akkawi,M & Jaber,S
Title of published work: “Synthesis, characterization and biological activity of new mixed ligand complexes of Zn(II) naproxen with nitrogen based ligands”
Name of Journal: European Journal of Medicinal Chemistry
Year: 2015
Volume: 89 (7)
Pages: 67–76
Publisher: Elsevier Masson SAS
Abstract:
A series of novel Zn(II) complexes [Zn2(nap)4] (1), [Zn(nap)21,10-phen](2), [Zn(nap)22,9-dmphen] (3), [Zn(nap)2(2-ampy)2] (4), [Zn(nap)2(imid)2] (5), [Zn(nap)2(1,2-dmimid)2] (6)(nap = naproxen, 1,10-phen = 1,10-phenanthroline, 2,9-dmphen = 2,9-dimethyl-1,10-phenanthroline, 2-ampy = 2-aminopyridine, imid = imidazole, 1,2-dmimid = 1,2-dimethyl imidazole) were synthesized and characterized using IR, UV–Vis, 1H NMR, 13C{1H} NMR spectroscopy. The crystal structure of complex 3 was determined using single-crystal X-ray diffraction. In order to assess the effect of the metal ions on the anti-bacterial activity, complexes 1–6 have been screened in vitro, against (G+) bacteria (Staphylococcus aureusand Micrococcus luteus) and (G−) bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis and Escherichia coli) using the agar well diffusion method. Complex 2 was the only complex that showed antibacterial activity against P. aeruginosa, where the complexation of the parent ligand 1,10-phenathroline enhanced significantly the activity. All the complexes showed different activity against the different bacteria, and were compared with activity of the parent ligands. The complexes were tested also for their anti-malarial activity using two methods: a semi-quantitative micro-assay and a previously self-developed quantitative in-vitro method. Both were used to study the efficiency of these complexes in inhibiting the formation of the Malaria pigment. This is considered an important target of many known anti-malarial drugs such as Chloroquine and Amodaquine. Results showed that the efficiency of complex 3 in preventing the formation of β-hematin was 75%. The efficiency of Amodiaquine as a standard drug was reported to give 92.5.
Contact info of the contact author (s):
Name: Mutaz Akkawi, PhD.
Address: Department of Biology, Faculty of Science & Technology, Al-Quds University
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
