Field of Research: Pharmacology
Name of author(s): Omar Deeb and Mohammad Goodarzi
Title of published work: QSAR of Antioxidants
Name of Journal or Book "Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment". Prof. Kunal Roy (Ed).
Year: 2015
Pages: 212-237
Journal volume: Chapter 6
Publisher’s name and address: IGI Golbal publishers
Abstract:
Antioxidants are substances that protect cells from the damaging effects of oxygen radicals, which are chemicals that play a part in some diseases such as cancer and others. Antioxidants are expected to be promising drugs in the management of these diseases by removing oxidative stress. Most of the modeling approaches involved in designing new antioxidants is based on Quantitative Structure-Activity Relationship (QSAR). A number of QSAR studies have been conducted to elucidate the structural requirements of antioxidants for their activities in order to predict the potency of these compounds with regard to the targeted activity and to direct the synthesis of more potent analogues. The main focus of this chapter is on the QSAR modeling of antioxidant compounds. The authors provide different QSAR studies of antioxidant compounds and try to compare between them in terms of the best models obtained and their use in designing potential new drugs.
Contact info of the contact author:
Name: Omar Deeb, PhD.
Address: Faculty of Pharmacy, Al-Quds University, Jerusalem,P.O Box: 51157, Palestine
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
