Field of Research: N/A
Name of author) (s): Bader M., Karaman R.
Title of published work: “Fumaric acid esters in psoriasis and multiple sclerosis”
Name of Journal: In book: Commonly Used Drugs - Uses, Side Effects, Bioavailability & Approaches to Improve it
Year: 2015
Edition: 1, Chapter: 8
Pages: 249-261
Publisher: Nova Science Publisher Inc.
Abstract:
Autoimmune diseases are the diseases of the modern century. Due to their complicated pathogenesis and the enrollment of many factors in disease initiation and progression, these diseases are considered uneasy to treat. Immune cells exist normally in our bodies. They are extremely essential for our survival against many pathogenic and foreign particles. Manipulating these cells through chemical and biological drugs has tremendous effects, usually with risks outweighing the benefits, as a result of the disturbance of cellular defense mechanisms. This chapter is devoted to the description of two different autoimmune diseases; multiple sclerosis (MS) and psoriasis. Up to date there is no known cure for MS and psoriasis. The available treatments approved by the FDA are mainly considered symptom relieving drugs and their major therapeutic action is only to slow the disease progression, and they lack the ability to eliminate the disease completely. A great devotion in this chapter was given to discuss several aspects regarding fumarate acid esters (FAEs) including; pharmacokinetics, mode of action, recommendations and specifically their potential as an effective treatment for psoriasis and MS.
Keywords:
Multiple Sclerosis (MS), psoriasis, fumaric acid esters
Contact author (s):
Name: Rafik Karaman, PhD.
Address: Al Quds University, Faculty of Pharmacy
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
