Field of Research: Anti-inflammatory
Name of author) (s): Abu-Jaish A., Mecca G., Jumaa S., Thawabteh A., Karaman R.
Title of published work: “Mefenamic acid Prodrugs and Codrugs- Two Decades of Development”
Name of Journal: World Journal of Pharmaceutical Research
Year: 2015
Volume: 4 (6)
Pages: 2408-2429
Publisher: WJPR
Abstract:
Prodrugs are bioreversible derivatives of drug molecules that undergo intermolecular or intramolecular reactions by enzymatic or chemical biotransformation in the human body to give the corresponding active parent drugs and a non-toxic promoiety. Prodrugs have been extensively and successfully used as a chemical tool for modification of the physicochemical, pharmacokinetic as well as pharmacodynamic characteristics of commonly used drugs and new drugs.This mini review focuses on the design, synthesis and pharmacological effects of several prodrugs and codrugs of the non-steroidal anti-inflammatory (NSAIDs), mefenamic acid. Exploitation of the prodrug approach has the potential to achieve a reduction of mefenamic acid GI (gastrointestinal) intolerance, enhance its bioavailability, mask its unpleasant sensation and prolong its duration of action. In addition, utilizing the prodrug concept migh enhance the bioavailability of the counter partner drug of mefenamic acid codrug by increasing its lipophilicity.
Keywords:
Anti-inflammatory drugs, Mefenamic acid prodrugs, Mefenamic acid codrugs, Prodrugs chemical approach, NSAIDs drugs, Prodrugs catalyzed by enzymes.
Contact author (s):
Name: Rafik Karaman, PhD.
Address: Al Quds University, Faculty of Pharmacy
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
