Field of Research: Clinical
Name of author) (s): Abu Helu R, Dudeen O, Barghouthi SA.
Title of published work: “Correlation between serum levels of vitamin B12 and anti-Helicobacter pylori IgA antibodies in vitamin B12 deficient Palestinian patients”
Name of Journal: Turkish Journal of Medical Sciences
Year: 2015
Volume: 45(3)
Pages: 627-33
Publisher: PMID: 26281330
Abstract:
Background/AIM:
H. pylori infection and vitamin B12 (vB12) deficiency have high prevalence rates among Palestinians. It was observed that most people who suffered from vB12 deficiency were positive for H. pylori.
Materials and methods:
The correlation between H. pylori infection and vB12 deficiency was investigated in a representative segment of the Palestinian population. ELISA was used to determine levels of vitamin B12 (vB12) and anti-H. pylori IgA in sera from 238 participants from Al-Khalil district (Hebron), Palestine.
Results:
There was a strong negative Pearson's correlation coefficient (r = -0.45; P = 0.00001) between levels of anti-H. pylori IgA and vB12 levels in sera drawn from 238 participants (133 patients and 105 control subjects). Two important contaminating variables were identified in this study: healthy control subjects with elevated anti-H. pylori IgA titers and vB12-deficient patients testing negative for anti-H. pylori IgA antibodies. The exclusion of the sources of contamination resulted in a stronger negative correlation; r = -0.58 (P = 0.00001).
Conclusion:
The study provided a good screening system that may predict vB12 deficiency before its actual manifestation. If not treated, asymptomatic subjects showing increased anti-H.pylori IgA titers (> 15 NTU/mL) are likely to be at risk of developing vB12 deficiency.Contact info of the
Contact author (s):
Name: Rasmi Abu Helu, PhD.
Address: Department of Medical Laboratory Sciences, Al-Quds University
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
