Field of Research: Drug Research
Name of author) (s): Shenderovich J, Feldman M, Kirmayer D, Al-Quntar A, Steinberg D, Lavy E and Friedman M.
Title of published work: “Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections”
Name of Journal: Int J Pharm
Year: 2015
Volume: 485(1-2)
Pages: 164-70
Publisher: Elsevier B.V.
Abstract:
Thiazolidinedione-8 (TZD-8) is an anti-quorum-sensing molecule that has the potential to effectively prevent catheter-associated urinary tract infections, a major healthcare challenge. Sustained-release drug-delivery systems can enhance drugs' therapeutic potential, by maintaining their therapeutic level and reducing their side effects. Varnishes for sustained release of TZD-8 based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit(®) RL) were developed. The main factors affecting release rate were found to be film thickness and presence of a hydrophilic or swellable polymer in the matrix. The release mechanism of ethylcellulose-based systems matched the Higuchi model. Selected varnishes were retained on catheters for at least 8 days. Sustained-release delivery systems of TZD-8 were active against Candida albicans biofilms. The present study demonstrates promising results en route to developing applications for the prevention of catheter-associated infections.
Keywords:
Catheter-associated infections; Modeling; Quorum sensing; Sustained release; Thiazolidinedione-8; Varnish
Contact info of the contact author (s):
Name: Abed-Alazeez Qantar, PhD.
Address: Department of Materials Engineering, Al-Quds University
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
