Field of Research: Dental Research
Name of author) (s): Feldman M, Shenderovich J, Al-Quntar AA, Friedman M and Steinberg D.
Title of published work: “Sustained release of a novel anti-quorum-sensing agent against oral fungal biofilms”
Name of Journal: Antimicrob Agents Chemother
Year: 2015
Volume: 59 (4)
Pages: 2265-72
Publisher: American Society for Microbiology
Abstract:
Thiazolidinedione-8 (S-8) has recently been identified as a potential anti-quorum-sensing/antibiofilm agent against bacteria and fungi. Based on these results, we investigated the possibility of incorporating S-8 in a sustained-release membrane (SRM) to increase its pharmaceutical potential against Candida albicans biofilm. We demonstrated that SRM containing S-8 inhibits fungal biofilm formation in a time-dependent manner for 72 h, due to prolonged release of S-8. Moreover, the SRM effectively delivered the agent in its active form to locations outside the membrane reservoir. In addition, eradication of mature biofilm by the SRM containing S-8 was also significant. Of note, S-8-containing SRM affected the characteristics of mature C. albicans biofilm, such as thickness, exopolysaccharide (EPS) production, and morphogenesis of fungal cells. The concept of using an antibiofilm agent with no antifungal activity incorporated into a sustained-release delivery system is new in medicine and dentistry. This concept of an SRM containing a quorum-sensing quencher with an antibiofilm effect could pave the way for combating oral fungal infectious diseases.
Contact info of the contact author (s):
Name: Abed-Alazeez Qantar, PhD.
Address: Department of Materials Engineering, Al-Quds University
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
